Serial founder effect

Serial founder effect have occurred when populations migrate over long distances. Such long distance migrations typically involve relatively rapid movements followed by periods of settlement. The populations in each migration carry only a subset of the genetic diversity carried from previous migrations. As a result, genetic differentiation tends to increase with geographic distance as described by the "Isolation by distance" model.8 The migration of humans out of Africa is characterized by serial founder effects.9 Africa has the highest genetic diversity which is consistent with an African origin of modern humans. After the initial migration from Africa, the Indian subcontinent was the first major settling point for modern humans. Consequently, India has the second highest genetic diversity in the world. In general, the genetic diversity of the Indian continent is a subset of Africa, and the genetic diversity outside Africa is a subset of India.1011